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Instead of being reabsorbed (as occurs in males who are not genetically susceptible to the disease), the hematoma leads to the recruitment of inflammatory cells and proinflammatory cytokines, which inevitably results in the formation of chronic inflammatory tissue that evolves towards fibrosis [20,21]

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Upon a 7-day course of kava, it was shown that the urinary excretion of NNAL increased, and 3-mA reduced, suggesting the ability to reduce the formation of NNK