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10.1083/jcb.201404140 219

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The extent to which the distal portion of l-Glu analogues can be modified and still retain potent inhibitory activity are illustrated by two novel natural products: the excitotoxin l-β- N -oxalyl-l-α,β-diaminopropionate (β-l-ODAP, K i ≈l-Cys 2 ≈ 40–100 µM) derived from Lathyrus sativus and the antimetabolite, antitumour agent l-alanosine from Streptomyces alanosinicus (Warren et al ., 2004