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Signal transducer and activator of transcription 3 (STAT3), a crucial cytoplasmic transcription factor in the STAT family, consists of 770 amino acids and possesses a complex domain structure, facilitating its diverse roles in cell signaling and gene regulation (Ma et al., 2020)

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Studies reveal that even a single or few DDR-signaling telomeres are sufficient to trigger replicative cell senescence [1]