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Retatrutide came up on JRE #2421 with Derek (More Plates More Dates) in December 2025, which is the source of the clips circulating as "Joe Rogan on retatrutide" — the discussion treated it as an investigational compound, not as something Rogan endorsed or said he uses
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Importantly, primary human ILC2s exhibited conserved NRF2 activation, glutathione accumulation, and reduced type 2 cytokine production in response to melatonin, underscoring clinical relevance