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The expression status of ANRIL may further prompt the development of PNFs into premalignant tumors such as atypical neurofibromas (ANF) or atypical neurofibromatous neoplasms of uncertain biologic potential (ANNUBP) ( Nf1- deficient mouse model by stimulating SCP self-renewal and promotion of tumorigenesis ( Taken together, different types of NF1 gene mutations and modifiers play an essential role in PNF tumorigenesis and tumor development

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