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K9 Advantix II for Large Dogs (21-55 lbs) Red Box Tech Wellness Enter the wonderful world ofMonthly Topical Flea, Tick & Mosquito Protection Product Description K9 Advantix II for Large Dogs provides broad spectrum, waterproof protection against fleas, ticks, mosquitoes, biting flies, and lice through contact kill action without painful biting. This once monthly topical treatment combines imidacloprid, permethrin, and pyriproxyfen to kill all flea life stages, prevent re infestation, and provide four weeks of continuous protection.