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dopamine necklace V | gold vermeil cufflinks one of the first alkaloidsdopamine necklace V 18k gold vermeil Dopamine is the molecule of motivation. Too much in one brain region and you hallucinate. Too little in another and you cannot focus. It is the neurotransmitter that explains why the same molecule solves two opposite neuropsychiatric problems. The Chemistry of Dopamine Dopamine is a catecholamine synthesized from tyrosine in the brain. The dopamine hypothesis of schizophrenia (1960s onward) proposed that excess D2